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BDBM162876 US9056859, 217

SMILES: Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(C2CC12)C(=O)Cc1ccc(nc1)-n1cnnn1

InChI Key: InChIKey=AUKXRHFMGMQRFC-CBNMVNINSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 162876   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))		BDBM162876
PNG
(US9056859, 217)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(C2CC12)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25N7O4/c1-14-16(3-4-17-18(14)12-35-24(17)34)21(32)11-29-6-7-30(20-9-19(20)29)23(33)8-15-2-5-22(25-10-15)31-13-26-27-28-31/h2-5,10,13,19-21,32H,6-9,11-12H2,1H3/t19?,20?,21-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 56n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9056859 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XS0
More data for this
Ligand-Target Pair