BDBM163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6

SMILES: Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1

InChI Key: InChIKey=SPNVMISESJDLQJ-UHFFFAOYSA-N

Data: 36 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 163869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	-11.2	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	-9.95	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	-9.95	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	-11.2	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	-9.91	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	-9.91	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	-9.91	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	-9.91	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	36	-9.43	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	36	-10.7	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	36	-9.43	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9475819 (2016) BindingDB Entry DOI: 10.7270/Q2DZ0771
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	41	-9.36	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	41	-9.36	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9475819 (2016) BindingDB Entry DOI: 10.7270/Q2DZ0771
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	41	-9.36	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	428	-9.12	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	428	-9.12	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	428	-9.12	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	428	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	428	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	428	-9.12	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	927	-8.64	n/a	n/a	n/a	n/a	n/a	n/a	40
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9475819 (2016) BindingDB Entry DOI: 10.7270/Q2DZ0771
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	927	-8.64	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	927	-8.64	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	927	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	>-7.16	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	>-7.16	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	>-7.16	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair
Orexin receptor type 1 (OX1) (Rattus norvegicus (Rat))	BDBM163869 (US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...) Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	n/a	4
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
					More data for this Ligand-Target Pair