BDBM164956 US10166239, Ex. 3-49-6a::US9067914, Ex. 3-49-6a
SMILES: COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
InChI Key: InChIKey=GJQVPMWSXKFICV-INIZCTEOSA-N
Data: 9 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Genzyme Corporation US Patent | Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter... | US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Genzyme Corporation US Patent | Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter... | US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Genzyme Corporation US Patent | Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter... | US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation US Patent | Assay Description In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ... | US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
GENZYME CORPORATION US Patent | Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter... | US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation US Patent | Assay Description In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100... | US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
GENZYME CORPORATION US Patent | Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter... | US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
GENZYME CORPORATION US Patent | Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter... | US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM164956 (US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation US Patent | Assay Description In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ... | US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN | |||||||||||
More data for this Ligand-Target Pair |