BindingDB PrimarySearch

BDBM164956 US10166239, Ex. 3-49-6a::US9067914, Ex. 3-49-6a

SMILES: COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1

InChI Key: InChIKey=GJQVPMWSXKFICV-XISACWJONA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 164956
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	25
Genzyme Corporation US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB
Genzyme Corporation US Patent					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	25
Genzyme Corporation US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB
Genzyme Corporation US Patent					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Genzyme Corporation US Patent					Assay Description Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...				US Patent US9067914 (2015) BindingDB Entry DOI: 10.7270/Q28051CB
Genzyme Corporation US Patent					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corporation US Patent									US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN
Genzyme Corporation US Patent					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-FMS) (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
GENZYME CORPORATION US Patent									US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD
GENZYME CORPORATION US Patent					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corporation US Patent									US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN
Genzyme Corporation US Patent					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
GENZYME CORPORATION US Patent									US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD
GENZYME CORPORATION US Patent					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB) (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GENZYME CORPORATION US Patent									US Patent US9611265 (2017) BindingDB Entry DOI: 10.7270/Q2S184KD
GENZYME CORPORATION US Patent					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM164956 (US10166239, Ex. 3-49-6a \| US9067914, Ex. 3-49-6a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corporation US Patent									US Patent US10166239 (2019) BindingDB Entry DOI: 10.7270/Q2WW7KSN
Genzyme Corporation US Patent					More data for this Ligand-Target Pair