BDBM173100 US9096589, (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyrimidin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-propan-1-ol::US9669029, 21 (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyrimidin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-propan-1-ol

SMILES: C[C@@H](CO)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1

InChI Key: InChIKey=DTXFIPHBCPVREE-HNNXBMFYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173100   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173100 (US9096589, (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a...) Show SMILES C[C@@H](CO)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C20H23N5OS/c1-13-9-14(2)25-10-16(22-20(25)21-13)6-7-19-23-17(18-5-4-8-27-18)11-24(19)15(3)12-26/h4-5,8-11,15,26H,6-7,12H2,1-3H3/t15-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM173100 (US9096589, (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a...) Show SMILES C[C@@H](CO)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C20H23N5OS/c1-13-9-14(2)25-10-16(22-20(25)21-13)6-7-19-23-17(18-5-4-8-27-18)11-24(19)15(3)12-26/h4-5,8-11,15,26H,6-7,12H2,1-3H3/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9096589 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TTM
					More data for this Ligand-Target Pair