null

SMILES: CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(Cl)cc1

InChI Key: InChIKey=FKMCOMBDOWMXCA-SBUREZEXSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 175754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175754 (US9688680, 299) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [V560G,D816V] (Homo sapiens (Human))	BDBM175754 (US9688680, 299) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description 10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM175754 (US9688680, 299) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair