BDBM176310 US9688696, 25

SMILES: CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O

InChI Key: InChIKey=HQOSHTKVDWZURV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176310   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM176310 (US9688696, 25) Show SMILES CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O Show InChI InChI=1S/C23H26Cl2N6O2/c1-3-16(2)31-23(33)30(15-26-31)18-9-7-17(8-10-18)28-11-13-29(14-12-28)22(32)27-21-19(24)5-4-6-20(21)25/h4-10,15-16H,3,11-14H2,1-2H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	741	n/a	n/a	n/a	n/a	7.4	25
Janssen Pharmaceutica N.V. US Patent					Assay Description DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...				US Patent US9688696 (2017) BindingDB Entry DOI: 10.7270/Q24X55ZP
					More data for this Ligand-Target Pair