BDBM17755 2-(3-sulfanylpropyl)pentanedioic acid::2-MPPA::CHEMBL303352::pentanedioic acid analogue, (RS)-3
SMILES: OC(=O)CCC(CCCS)C(O)=O
InChI Key: InChIKey=FNLNSQHJKVQCBP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Guilford | Assay Description GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ... | J Med Chem 48: 2319-24 (2005) Article DOI: 10.1021/jm049258g BindingDB Entry DOI: 10.7270/Q2D50K77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.4 | 37 |
MGI Pharma | Assay Description GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ... | J Med Chem 49: 2876-85 (2006) Article DOI: 10.1021/jm051019l BindingDB Entry DOI: 10.7270/Q28C9TJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Guilford Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of N-acetyl-L-aspartyl-[3H]-L-glutamate binding to glutamate carboxypeptidase II (GCP II) | J Med Chem 46: 1989-96 (2003) Article DOI: 10.1021/jm020515w BindingDB Entry DOI: 10.7270/Q2SQ8ZRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Guilford Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Glutamate carboxypeptidase II | Bioorg Med Chem Lett 13: 2097-100 (2003) BindingDB Entry DOI: 10.7270/Q2Z60NF2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assay | J Med Chem 55: 5922-32 (2012) Article DOI: 10.1021/jm300488m BindingDB Entry DOI: 10.7270/Q21J9BWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Research Institute Curated by ChEMBL | Assay Description Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]G | Bioorg Med Chem Lett 20: 7222-5 (2010) Article DOI: 10.1016/j.bmcl.2010.10.109 BindingDB Entry DOI: 10.7270/Q2GB24B9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Curated by ChEMBL | Assay Description Inhibition of GCP2 (unknown origin) | J Med Chem 57: 243-7 (2014) Article DOI: 10.1021/jm401703a BindingDB Entry DOI: 10.7270/Q2HH6MJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Guilford Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP II | Bioorg Med Chem Lett 13: 2097-100 (2003) BindingDB Entry DOI: 10.7270/Q2Z60NF2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17755 (2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins School of Medicine Curated by ChEMBL | Assay Description Inhibition of GCP-2 (unknown origin) | Drug Metab Dispos 40: 2315-23 (2012) Article DOI: 10.1124/dmd.112.046821 BindingDB Entry DOI: 10.7270/Q2W66NG5 | |||||||||||
More data for this Ligand-Target Pair |