Reaction Details |
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Target | Glutamate carboxypeptidase 2 |
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Ligand | BDBM17755 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_71703 (CHEMBL680917) |
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IC50 | 90±n/a nM |
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Citation | Majer, P; Jackson, PF; Delahanty, G; Grella, BS; Ko, YS; Li, W; Liu, Q; Maclin, KM; Poláková, J; Shaffer, KA; Stoermer, D; Vitharana, D; Wang, EY; Zakrzewski, A; Rojas, C; Slusher, BS; Wozniak, KM; Burak, E; Limsakun, T; Tsukamoto, T Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem46:1989-96 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutamate carboxypeptidase 2 |
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Name: | Glutamate carboxypeptidase 2 |
Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
Type: | PROTEIN |
Mol. Mass.: | 84333.66 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1497035 |
Residue: | 750 |
Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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BDBM17755 |
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n/a |
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Name | BDBM17755 |
Synonyms: | 2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | CHEMBL303352 | pentanedioic acid analogue, (RS)-3 |
Type | Small organic molecule |
Emp. Form. | C8H14O4S |
Mol. Mass. | 206.259 |
SMILES | OC(=O)CCC(CCCS)C(O)=O |
Structure |
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