BDBM185587 US9156852, 50::USRE47451, Example 50
SMILES: Cc1ccc2c(Nc3ccc(OC(F)F)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
InChI Key: InChIKey=WSVRCSFMNFUWEQ-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM185587 (US9156852, 50 | USRE47451, Example 50) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
HANMI PHARM. CO., LTD US Patent | Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty... | US Patent US9156852 (2015) BindingDB Entry DOI: 10.7270/Q24T6H4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B-RAF V600E (Homo sapiens (Human)) | BDBM185587 (US9156852, 50 | USRE47451, Example 50) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
HANMI PHARM. CO., LTD US Patent | Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty... | US Patent US9156852 (2015) BindingDB Entry DOI: 10.7270/Q24T6H4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-RAF (Y340D Y341D) (Homo sapiens (Human)) | BDBM185587 (US9156852, 50 | USRE47451, Example 50) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC Curated by PubChem BioAssay | Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty... | PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2XW4N61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B-Raf Protein Kinase (Homo sapiens (Human)) | BDBM185587 (US9156852, 50 | USRE47451, Example 50) | PDB MMDB Reactome pathway B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC Curated by PubChem BioAssay | Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty... | PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2XW4N61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B-RAF V600E (Homo sapiens (Human)) | BDBM185587 (US9156852, 50 | USRE47451, Example 50) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC Curated by PubChem BioAssay | Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty... | PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2XW4N61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM185587 (US9156852, 50 | USRE47451, Example 50) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
HANMI PHARM. CO., LTD US Patent | Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty... | US Patent US9156852 (2015) BindingDB Entry DOI: 10.7270/Q24T6H4D | |||||||||||
More data for this Ligand-Target Pair |