BDBM189867 US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-5- ([1,2,4]triazolo[1,5- a]pyridin-2- ylamino)phenyl]-1,3- thiazol-2-yl}-5,6,7,8- tetrahydronaphthalene-2- carboxylic acid

SMILES: Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O

InChI Key: InChIKey=BAVFCYKYVATCIC-HHHXNRCGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM189867 (US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-...) Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O |r| Show InChI InChI=1S/C27H23N5O3S/c1-16-11-19(14-20(12-16)29-26-30-23-6-2-3-10-32(23)31-26)22-15-28-25(36-22)27(35)9-4-5-17-13-18(24(33)34)7-8-21(17)27/h2-3,6-8,10-15,35H,4-5,9H2,1H3,(H,29,31)(H,33,34)/t27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.129	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9670196 (2017) BindingDB Entry DOI: 10.7270/Q2D798MJ
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