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SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CC3CC(=NO3)c3cc(ccc3Cl)C(F)(F)F)CCn2c1=O

InChI Key: InChIKey=QPNULTTYKAGARF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193042   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193042
PNG
(US9193726, 30)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CC(=NO3)c3cc(ccc3Cl)C(F)(F)F)CCn2c1=O |c:17|
Show InChI InChI=1S/C23H19ClF3N5O3/c1-13-10-31(12-28-13)19-4-5-20-21(33)30(6-7-32(20)22(19)34)11-15-9-18(29-35-15)16-8-14(23(25,26)27)2-3-17(16)24/h2-5,8,10,12,15H,6-7,9,11H2,1H3
PDB
MMDB

UniProtKB/SwissProt

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antibodypedia
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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 711n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair