BDBM193719 2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-fluorophenyl)hydrazinecarbothioamide (2)
SMILES: Fc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
InChI Key: InChIKey=RATHBSGZCUJXBA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
beta-Glucuronidase (β-glucuronidase) (Homo sapiens (Human)) | BDBM193719 (2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-fluoro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of KwaZulu-Natal Curated by ChEMBL | Assay Description Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 mins | Eur J Med Chem 187: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
beta-Glucuronidase (β-glucuronidase) (Homo sapiens (Human)) | BDBM193719 (2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-fluoro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Universiti Teknologi MARA | Assay Description β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr... | Bioorg Chem 68: 56-63 (2016) Article DOI: 10.1016/j.bioorg.2016.07.008 BindingDB Entry DOI: 10.7270/Q2RV0MGS | |||||||||||
More data for this Ligand-Target Pair |