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SMILES: Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cn[nH]c1)-c1noc(n1)C1CC(F)(F)C1

InChI Key: InChIKey=RMXVIPAFTSRMND-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193949   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM193949
PNG
(US9199981, F40)
Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cn[nH]c1)-c1noc(n1)C1CC(F)(F)C1
Show InChI InChI=1S/C24H19F2N7O2/c1-13-2-3-14(21-31-23(35-32-21)16-7-24(25,26)8-16)6-18(13)30-22(34)19-11-27-20-5-4-15(12-33(19)20)17-9-28-29-10-17/h2-6,9-12,16H,7-8H2,1H3,(H,28,29)(H,30,34)
PDB

UniProtKB/SwissProt

antibodypedia
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Similars
US Patent
n/an/a 9n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...

US Patent US9199981 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TKJ
More data for this
Ligand-Target Pair