BDBM20892 3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-{3-[({[2-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}-1H-pyrazole-5-carboxamide::Pyrazole, 20c

SMILES: CCNC(=O)c1[nH]nc(c1-c1cccc(CNCc2ccccc2C(F)(F)F)c1)-c1cc(Cl)c(O)cc1O

InChI Key: InChIKey=ZTEUZIUQSSFLER-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20892   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM20892 (3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-{3-[({[...) Show SMILES CCNC(=O)c1[nH]nc(c1-c1cccc(CNCc2ccccc2C(F)(F)F)c1)-c1cc(Cl)c(O)cc1O Show InChI InChI=1S/C27H24ClF3N4O3/c1-2-33-26(38)25-23(24(34-35-25)18-11-20(28)22(37)12-21(18)36)16-8-5-6-15(10-16)13-32-14-17-7-3-4-9-19(17)27(29,30)31/h3-12,32,36-37H,2,13-14H2,1H3,(H,33,38)(H,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	231	n/a	3.11E+3	n/a	n/a	7.4	22
Vernalis (R&D) Ltd					Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...				J Med Chem 51: 196-218 (2008) Article DOI: 10.1021/jm701018h BindingDB Entry DOI: 10.7270/Q2JW8C5C
					More data for this Ligand-Target Pair