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BDBM21360 7-ethoxy-3H-phenoxazin-3-one::7-ethoxyresorufin::Ethoxyresorufin::US9216974, Ethoxy-resorufin

SMILES: CCOc1ccc2nc3ccc(=O)cc3oc2c1

InChI Key: InChIKey=CRCWUBLTFGOMDD-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 21360   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (Human))
BDBM21360
PNG
(7-ethoxy-3H-phenoxazin-3-one | 7-ethoxyresorufin |...)
Show SMILES CCOc1ccc2nc3ccc(=O)cc3oc2c1
Show InChI InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3
PDB
MMDB

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Patents

US Patent
262n/an/an/an/an/an/an/an/a



WASHINGTON UNIVERSITY

US Patent


Assay Description
To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ...


US Patent US9216974 (2015)


BindingDB Entry DOI: 10.7270/Q2WD3ZCG
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM21360
PNG
(7-ethoxy-3H-phenoxazin-3-one | 7-ethoxyresorufin |...)
Show SMILES CCOc1ccc2nc3ccc(=O)cc3oc2c1
Show InChI InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3
PDB
MMDB

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Article
PubMed
n/an/a 500n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human CYP1A2


J Med Chem 53: 7129-39 (2010)


Article DOI: 10.1021/jm100832d
BindingDB Entry DOI: 10.7270/Q2CJ8DQZ
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM21360
PNG
(7-ethoxy-3H-phenoxazin-3-one | 7-ethoxyresorufin |...)
Show SMILES CCOc1ccc2nc3ccc(=O)cc3oc2c1
Show InChI InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

KEGG
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human CYP1A2


J Med Chem 53: 374-91 (2010)


Article DOI: 10.1021/jm901319p
BindingDB Entry DOI: 10.7270/Q2WQ03X8
More data for this
Ligand-Target Pair