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BDBM21939 8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-(2-methanesulfonylethyl)-1H-imidazol-4-yl]methyl}amino)quinoline-3-carbonitrile::Cyanoquinoline, 50

SMILES: CS(=O)(=O)CCn1cnc(CNc2cc(Br)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)c1

InChI Key: InChIKey=LTGJVIHVLWWYKD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21939   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM21939
PNG
(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-...)
Show SMILES CS(=O)(=O)CCn1cnc(CNc2cc(Br)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)c1
Show InChI InChI=1S/C23H19BrClFN6O2S/c1-35(33,34)5-4-32-12-17(30-13-32)11-28-16-6-18-22(31-15-2-3-21(26)20(25)8-15)14(9-27)10-29-23(18)19(24)7-16/h2-3,6-8,10,12-13,28H,4-5,11H2,1H3,(H,29,31)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...


J Med Chem 50: 4728-45 (2007)


Article DOI: 10.1021/jm070436q
BindingDB Entry DOI: 10.7270/Q2891441
More data for this
Ligand-Target Pair