BDBM21949 2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl]-1H-1,2,3,4-tetrazol-1-yl}ethyl (3R)-3-acetamidopyrrolidine-1-carboxylate::Tetrazole-based compound, 15

SMILES: CC(=O)N[C@@H]1CCN(C1)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N

InChI Key: InChIKey=QFFIHUHLUGLDBF-RTBURBONSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21949   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin receptor (Homo sapiens (Human))	BDBM21949 (2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...) Show SMILES CC(=O)N[C@@H]1CCN(C1)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |r| Show InChI InChI=1S/C23H34N8O5/c1-16(32)25-18-9-10-30(13-18)22(34)36-12-11-31-20(27-28-29-31)19(26-21(33)23(2,3)24)15-35-14-17-7-5-4-6-8-17/h4-8,18-19H,9-15,24H2,1-3H3,(H,25,32)(H,26,33)/t18-,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.30	n/a	n/a	7.2	22
Bristol-Myers Squibb Pharmaceutical Research Institute					Assay Description The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio...				J Med Chem 50: 5890-3 (2007) Article DOI: 10.1021/jm7010595 BindingDB Entry DOI: 10.7270/Q24J0CCV
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