BDBM222064 N-(3,4-dichlorophenyl)-2-(4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)benzoyl)hydrazinecarbothioamide (5)

SMILES: Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=MRDLPGOODKUKDP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
α-glucosidase (Saccharomyces cerevisiae S288c (Baker's yeast))	BDBM222064 (N-(3,4-dichlorophenyl)-2-(4-(5,6-dimethyl-1H-benzo...) Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C23H19Cl2N5OS/c1-12-9-19-20(10-13(12)2)28-21(27-19)14-3-5-15(6-4-14)22(31)29-30-23(32)26-16-7-8-17(24)18(25)11-16/h3-11H,1-2H3,(H,27,28)(H,29,31)(H2,26,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.19E+4	n/a	n/a	n/a	n/a	6.8	37
Universiti Teknologi MARA (UiTM)					Assay Description The enzyme inhibition was evaluated according to the method previously reported by Zawawi et al. [Zawawi et al., Bioorg. Chem., 23:3119] with slight ...				Bioorg Chem 70: 184-191 (2017) Article DOI: 10.1016/j.bioorg.2016.12.009 BindingDB Entry DOI: 10.7270/Q27P8X71
					More data for this Ligand-Target Pair