BDBM222189 6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7k)

SMILES: COc1ccc(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C

InChI Key: InChIKey=NGSBQVKCJPOFSC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 222189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM222189 (6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxy...) Show SMILES COc1ccc(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C Show InChI InChI=1S/C20H20N2O4S/c1-22(2)15-9-8-14-19-13(15)5-4-6-18(19)27(24,25)21-20(14)12-7-10-17(26-3)16(23)11-12/h4-11,20-21,23H,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM222189 (6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxy...) Show SMILES COc1ccc(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C Show InChI InChI=1S/C20H20N2O4S/c1-22(2)15-9-8-14-19-13(15)5-4-6-18(19)27(24,25)21-20(14)12-7-10-17(26-3)16(23)11-12/h4-11,20-21,23H,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
					More data for this Ligand-Target Pair