BDBM22326 2-amino-5-hydroxyindole, 3l::ethyl 5-hydroxy-2-[(1-phenylethyl)amino]-1H-indole-3-carboxylate
SMILES: CCOC(=O)c1c(NC(C)c2ccccc2)[nH]c2ccc(O)cc12
InChI Key: InChIKey=PUPSFGSGDXDHQE-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arachidonate 5-lipoxygenase (Homo sapiens (Human)) | BDBM22326 (2-amino-5-hydroxyindole, 3l | ethyl 5-hydroxy-2-[(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Friedrich Alexander University Erlangen | Assay Description Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut... | J Med Chem 49: 4327-32 (2006) Article DOI: 10.1021/jm050801i BindingDB Entry DOI: 10.7270/Q2PC30PQ | |||||||||||
More data for this Ligand-Target Pair |