BDBM22464 2-Amino-1,3-thiazol-4(5H)-one, 5g::2-{bicyclo[2.2.1]heptan-7-ylamino}-5-ethyl-5-methyl-4,5-dihydro-1,3-thiazol-4-one::5-Ethyl-5-methyl-2-(7-norbornylamino)-1,3-thiazol-4(5H)-one

SMILES: CCC1(C)SC(NC2C3CCC2CC3)=NC1=O

InChI Key: InChIKey=XMGUIUDPFNFXJZ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22464   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM22464 (2-Amino-1,3-thiazol-4(5H)-one, 5g | 2-{bicyclo[2.2...) Show SMILES CCC1(C)SC(NC2C3CCC2CC3)=NC1=O |c:15,TLB:6:7:9.10:12.13| Show InChI InChI=1S/C13H20N2OS/c1-3-13(2)11(16)15-12(17-13)14-10-8-4-5-9(10)7-6-8/h8-10H,3-7H2,1-2H3,(H,14,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	372	-8.68	n/a	n/a	n/a	n/a	n/a	7.2	22
Biovitrum AB					Assay Description The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...				J Med Chem 51: 2933-43 (2008) Article DOI: 10.1021/jm701551j BindingDB Entry DOI: 10.7270/Q2HM56Q8
					More data for this Ligand-Target Pair