BDBM22473 2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one::2-Amino-1,3-thiazol-4(5H)-one, 8b::2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylamino}-1-thia-3-azaspiro[4.4]non-2-en-4-one
SMILES: O=C1N=C(NC23CC4CC2CC(C3)C4)SC11CCCC1
InChI Key: InChIKey=GXHSOLWRHSMNFU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM22473 (2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | -11.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Biovitrum AB | Assay Description The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA... | J Med Chem 51: 2933-43 (2008) Article DOI: 10.1021/jm701551j BindingDB Entry DOI: 10.7270/Q2HM56Q8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse)) | BDBM22473 (2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 120 | -9.34 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Biovitrum AB | Assay Description Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ... | J Med Chem 51: 2933-43 (2008) Article DOI: 10.1021/jm701551j BindingDB Entry DOI: 10.7270/Q2HM56Q8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) (Rattus norvegicus (rat)) | BDBM22473 (2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 180 | -9.10 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Biovitrum AB | Assay Description Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ... | J Med Chem 51: 2933-43 (2008) Article DOI: 10.1021/jm701551j BindingDB Entry DOI: 10.7270/Q2HM56Q8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human)) | BDBM22473 (2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB | Assay Description The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2... | J Med Chem 51: 2933-43 (2008) Article DOI: 10.1021/jm701551j BindingDB Entry DOI: 10.7270/Q2HM56Q8 | |||||||||||
More data for this Ligand-Target Pair |