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BDBM22549 2-[3-(1H-imidazol-4-ylmethyl)phenyl]-3-oxa-1-azaspiro[4.4]non-1-ene::4-Benzyl-1H-imidazole derivative, 27

SMILES: C(c1cnc[nH]1)c1cccc(c1)C1=NC2(CCCC2)CO1

InChI Key: InChIKey=LJRAXUNIHUDNOP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22549   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22549
PNG
(2-[3-(1H-imidazol-4-ylmethyl)phenyl]-3-oxa-1-azasp...)
Show SMILES C(c1cnc[nH]1)c1cccc(c1)C1=NC2(CCCC2)CO1 |t:14|
Show InChI InChI=1S/C17H19N3O/c1-2-7-17(6-1)11-21-16(20-17)14-5-3-4-13(8-14)9-15-10-18-12-19-15/h3-5,8,10,12H,1-2,6-7,9,11H2,(H,18,19)
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KEGG

UniProtKB/SwissProt

DrugBank
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PC cid
PC sid
UniChem
Article
PubMed
40 -10.1n/an/an/an/an/a7.425



VU University Amsterdam



Assay Description
Ligand displacement assays were performed on CHO cells membranes expressing hH3R. Retained radioactivity was determined by liquid scintillation count...


J Med Chem 51: 2944-53 (2008)


Article DOI: 10.1021/jm7014149
BindingDB Entry DOI: 10.7270/Q24F1P2W
More data for this
Ligand-Target Pair