BDBM22864 2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1-amine::Histaprodifen

SMILES: NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1

InChI Key: InChIKey=BPZGZNLONLANFE-UHFFFAOYSA-N

Data: 1 KI  1 IC50  14 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 22864   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	7.4	37
Vrije Universiteit Amsterdam					Assay Description Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...				J Pharmacol Exp Ther 314: 1310-21 (2005) Article DOI: 10.1124/jpet.105.087965 BindingDB Entry DOI: 10.7270/Q2KD1W6V
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.776	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonism of guinea pig ileum contraction at 100 nM mepyramine				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
HTR4 (RAT)	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>3.16E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 4 receptor of rat				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Homo sapiens (Human))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 3 receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	9.12	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nM				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	6.46E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 2A receptor of rat				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 1B receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.977	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.55E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Muscarinic acetylcholine receptor M3 of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.47E+4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Histamine H2 receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
HRH3 (GUINEA PIG)	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>1.58E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Histamine H3 receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.58	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (GUINEA PIG)	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	4.57E+4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	9.12	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Maximum response (E max) against Histamine H1 receptor in rat aorta				J Med Chem 46: 5458-70 (2003) Article DOI: 10.1021/jm0309147 BindingDB Entry DOI: 10.7270/Q2CN753N
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM22864 (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1...) Show SMILES NCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibitory activity against human Histamine H1 receptor				J Med Chem 46: 5812-24 (2003) Article DOI: 10.1021/jm030936t BindingDB Entry DOI: 10.7270/Q2GT5PF7
					More data for this Ligand-Target Pair