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BDBM234280 5-(4-Chlorophenyl)-4-methyl-1-(pyridin-2-yl)-N-(4-methylcyclohexyl)-1H-pyrazole-3-carboxamide (12j)

SMILES: CC1CCC(CC1)NC(=O)c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccccn1

InChI Key: InChIKey=WYYVOMVLKYQGJV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 234280   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cannabinoid receptor 1


(Cricetulus griseus (Chinese hamster))		BDBM234280
PNG
(5-(4-Chlorophenyl)-4-methyl-1-(pyridin-2-yl)-N-(4-...)
Show SMILES CC1CCC(CC1)NC(=O)c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccccn1 |(49.96,-18.83,;48.43,-18.67,;47.8,-17.26,;46.27,-17.1,;45.37,-18.34,;45.99,-19.75,;47.52,-19.91,;43.83,-18.18,;42.93,-19.43,;43.56,-20.84,;41.4,-19.27,;40.63,-17.93,;39.12,-18.25,;38.96,-19.79,;40.37,-20.41,;40.69,-21.92,;37.63,-20.56,;37.63,-22.1,;36.29,-22.87,;34.96,-22.1,;33.63,-22.87,;34.96,-20.56,;36.29,-19.79,;37.98,-17.22,;36.51,-17.7,;35.37,-16.67,;35.69,-15.16,;37.15,-14.69,;38.3,-15.72,)|
Show InChI InChI=1S/C23H25ClN4O/c1-15-6-12-19(13-7-15)26-23(29)21-16(2)22(17-8-10-18(24)11-9-17)28(27-21)20-5-3-4-14-25-20/h3-5,8-11,14-15,19H,6-7,12-13H2,1-2H3,(H,26,29)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 612n/an/an/an/an/an/a



NanChang University School of Pharmaceutical Science



Assay Description
The target compounds were evaluated using a binding assay towards the CB1 receptor expressed on the membranes of Chinese hamster ovarian (CHO) cells....

J Enzyme Inhib Med Chem 26: 222-30 (2011)


Article DOI: 10.3109/14756366.2010.491794
BindingDB Entry DOI: 10.7270/Q26D5RW8
More data for this
Ligand-Target Pair