BDBM236284 US9365576, 37

SMILES: COc1ccc(cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)NOCCO

InChI Key: InChIKey=MQCHZUMQAXKSCI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 236284   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM236284 (US9365576, 37) Show SMILES COc1ccc(cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)NOCCO Show InChI InChI=1S/C32H31Cl2N3O5/c1-18(2)36-27(24-15-21(8-12-28(24)41-4)31(39)35-42-14-13-38)17-25-30(36)29(20-6-10-22(33)11-7-20)37(32(25)40)26-16-23(34)9-5-19(26)3/h5-12,15-18,29,38H,13-14H2,1-4H3,(H,35,39)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM2 (Homo sapiens (Human))	BDBM236284 (US9365576, 37) Show SMILES COc1ccc(cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)NOCCO Show InChI InChI=1S/C32H31Cl2N3O5/c1-18(2)36-27(24-15-21(8-12-28(24)41-4)31(39)35-42-14-13-38)17-25-30(36)29(20-6-10-22(33)11-7-20)37(32(25)40)26-16-23(34)9-5-19(26)3/h5-12,15-18,29,38H,13-14H2,1-4H3,(H,35,39)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.125	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM4 (Homo sapiens (Human))	BDBM236284 (US9365576, 37) Show SMILES COc1ccc(cc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)NOCCO Show InChI InChI=1S/C32H31Cl2N3O5/c1-18(2)36-27(24-15-21(8-12-28(24)41-4)31(39)35-42-14-13-38)17-25-30(36)29(20-6-10-22(33)11-7-20)37(32(25)40)26-16-23(34)9-5-19(26)3/h5-12,15-18,29,38H,13-14H2,1-4H3,(H,35,39)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	327	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair