BDBM236484 US9365576, 240

SMILES: COc1ncc(-c2cc3C(=O)N(C(c3n2C2CC2)c2ccc(Cl)cc2)c2cc(C)c(=O)n(C)c2)c(OC)n1

InChI Key: InChIKey=OLPKXDUPEZNXEA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 236484   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM4 (Homo sapiens (Human))	BDBM236484 (US9365576, 240) Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C2CC2)c2ccc(Cl)cc2)c2cc(C)c(=O)n(C)c2)c(OC)n1 Show InChI InChI=1S/C28H26ClN5O4/c1-15-11-19(14-32(2)26(15)35)34-23(16-5-7-17(29)8-6-16)24-20(27(34)36)12-22(33(24)18-9-10-18)21-13-30-28(38-4)31-25(21)37-3/h5-8,11-14,18,23H,9-10H2,1-4H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.76E+4	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM2 (Homo sapiens (Human))	BDBM236484 (US9365576, 240) Show SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C2CC2)c2ccc(Cl)cc2)c2cc(C)c(=O)n(C)c2)c(OC)n1 Show InChI InChI=1S/C28H26ClN5O4/c1-15-11-19(14-32(2)26(15)35)34-23(16-5-7-17(29)8-6-16)24-20(27(34)36)12-22(33(24)18-9-10-18)21-13-30-28(38-4)31-25(21)37-3/h5-8,11-14,18,23H,9-10H2,1-4H3	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.3	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair