BDBM237182 Ceftizoxime

SMILES: CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1

InChI Key: InChIKey=NNULBSISHYWZJU-LLKWHZGFSA-N

Data: 5 KI  5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 237182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutathione reductase (GR) (Homo sapiens (Human))	BDBM237182 (Ceftizoxime) Show SMILES CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1 |c:11| Show InChI InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem	Article PubMed	2.28E+4	n/a	3.97E+4	n/a	n/a	n/a	n/a	8.0	n/a
Ondokuz Mayis University					Assay Description Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25°C. The assay system contained 100 mM Tris-...				J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM237182 (Ceftizoxime) Show SMILES CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1 |c:11| Show InChI InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem	Article PubMed	5.18E+4	-5.84	7.91E+4	n/a	n/a	n/a	n/a	7.4	25
Erzincan University					Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e...				J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM237182 (Ceftizoxime) Show SMILES CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1 |c:11| Show InChI InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem	Article PubMed	8.61E+4	-5.54	7.94E+4	n/a	n/a	n/a	n/a	7.4	25
Erzincan University					Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e...				J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK
					More data for this Ligand-Target Pair
Glutathione peroxidase 1 (GPx) (Homo sapiens (Human))	BDBM237182 (Ceftizoxime) Show SMILES CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1 |c:11| Show InChI InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem	Article PubMed	1.21E+5	n/a	1.86E+5	n/a	n/a	n/a	n/a	7.0	n/a
Ondokuz Mayis University					Assay Description Glutathione peroxidase was assayed in a l-ml system containing 0.1 M potassium phosphate buffer, pH 7.0, 0.2 mM NADPH, 1 i.u. glutathione reductase, ...				J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4
					More data for this Ligand-Target Pair
Glutathione S-transferase (GST) (Homo sapiens (Human))	BDBM237182 (Ceftizoxime) Show SMILES CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1 |c:11| Show InChI InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem	Article PubMed	1.65E+5	n/a	2.78E+5	n/a	n/a	n/a	n/a	6.5	n/a
Ondokuz Mayis University					Assay Description Enzymatic activity was determined spectrophotometrically by measuring the conjugation of CDNB with GSH. The 1 ml assay mixture contained 0.5 mM CDNB,...				J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4
					More data for this Ligand-Target Pair