BDBM239011 US10028934, Compound 6::US10478423, Cpd. 6::US9408850, 6::US9597317, 6

SMILES: CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12

InChI Key: InChIKey=BWPSQPNBLNXPHV-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 239011   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 [564-993] (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	248	n/a	n/a	n/a	n/a	7.9	28
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.89E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	248	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	248	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	248	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.89E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair