BDBM241959 5-(2-(4-Morpholinophenyl)hydrazono-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione (15)
SMILES: O=[#6]1-[#7]-[#6](=S)-[#7]-[#6](=O)\[#6]-1=[#7]/[#7]-c1ccc(cc1)-[#7]-1-[#6]-[#6]-[#8]-[#6]-[#6]-1
InChI Key: InChIKey=MDZQPRHNZQFNEJ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human)) | BDBM241959 (5-(2-(4-Morpholinophenyl)hydrazono-dihydro-2-thiox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.23E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
East China University of Science and Technology | Assay Description The inhibition assays against RSK2 in vitro were determined by ADP Quest® (DiscoveRx) in 96-well flat-bottom plates according to the manufacturer... | J Enzyme Inhib Med Chem 28: 747-52 (2013) Article DOI: 10.3109/14756366.2012.681651 BindingDB Entry DOI: 10.7270/Q2DV1HT9 | |||||||||||
More data for this Ligand-Target Pair |