Found 19 hits for monomerid = 24777 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 6.5 | 37 |
Bryn Mawr College
| Assay Description The IC50 inhibition assays were performed in a 96-well microtiter plate format using purified recombinant IDO, which was added to the substrate, L-tr... |
J Med Chem 51: 1706-18 (2008)
Article DOI: 10.1021/jm7014155 BindingDB Entry DOI: 10.7270/Q2VD6WSV |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.1c01222 BindingDB Entry DOI: 10.7270/Q2T72NFX |
More data for this Ligand-Target Pair | |
Amine oxidase
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 4.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University
| Assay Description The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan... |
Chem Biol Drug Des 87: 737-46 (2016)
Article DOI: 10.1111/cbdd.12708 BindingDB Entry DOI: 10.7270/Q2MG7N84 |
More data for this Ligand-Target Pair | |
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [1-175]
(Yersinia pestis) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Brookhaven National Laboratory
| Assay Description The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ... |
Biochemistry 55: 1091-9 (2016)
Article DOI: 10.1021/acs.biochem.5b00832 BindingDB Entry DOI: 10.7270/Q2CN72P1 |
More data for this Ligand-Target Pair | |
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
(Francisella tularensis) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Brookhaven National Laboratory
| Assay Description The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ... |
Biochemistry 55: 1091-9 (2016)
Article DOI: 10.1021/acs.biochem.5b00832 BindingDB Entry DOI: 10.7270/Q2CN72P1 |
More data for this Ligand-Target Pair | |
5-lipoxygenase
(Bos taurus) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
Reactome pathway
UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Westfälische Wilhelms-Universität Münster
Curated by ChEMBL
| Assay Description 5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL) |
J Med Chem 40: 3773-80 (1997)
Article DOI: 10.1021/jm970292n BindingDB Entry DOI: 10.7270/Q20R9NJN |
More data for this Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of Pin1 (unknown origin) using Suc-Ala-Glu-Pro-Phe-4-nitroanilide as substrate after 30 mins by protease-coupled assay |
Bioorg Med Chem Lett 24: 5612-5 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.087 BindingDB Entry DOI: 10.7270/Q2MG7R4K |
More data for this Ligand-Target Pair | |
M-phase inducer phosphatase 2
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Polytechnic Institute and State University
Curated by ChEMBL
| Assay Description Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli |
Bioorg Med Chem 17: 2276-81 (2009)
Article DOI: 10.1016/j.bmc.2008.10.090 BindingDB Entry DOI: 10.7270/Q21J99MN |
More data for this Ligand-Target Pair | |
Dual specificity protein phosphatase 6
(Rattus norvegicus) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Polytechnic Institute and State University
Curated by ChEMBL
| Assay Description Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3) |
Bioorg Med Chem 17: 2276-81 (2009)
Article DOI: 10.1016/j.bmc.2008.10.090 BindingDB Entry DOI: 10.7270/Q21J99MN |
More data for this Ligand-Target Pair | |
Dual specificity protein phosphatase 1
(Mus musculus) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Polytechnic Institute and State University
Curated by ChEMBL
| Assay Description Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cells |
Bioorg Med Chem 17: 2276-81 (2009)
Article DOI: 10.1016/j.bmc.2008.10.090 BindingDB Entry DOI: 10.7270/Q21J99MN |
More data for this Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of Pin1 (unknown origin) assessed as reduction in peptidyl-prolyl isomerase activity incubated for 30 mins using Suc-Ala-Glu-cis-Pro-Phe-4... |
Bioorg Med Chem 25: 5441-5451 (2017)
Article DOI: 10.1016/j.bmc.2017.08.002 BindingDB Entry DOI: 10.7270/Q23N25V4 |
More data for this Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His6-tagged Pin1 PPIase activity expressed in Escherichia coli BL21 using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as su... |
Bioorg Med Chem 26: 2186-2197 (2018)
Article DOI: 10.1016/j.bmc.2018.03.024 BindingDB Entry DOI: 10.7270/Q2RN3BH0 |
More data for this Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal His6-tagged human Pin1 using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as substrate preincubated for 30 mins follow... |
Bioorg Med Chem Lett 28: 3187-3193 (2018)
Article DOI: 10.1016/j.bmcl.2018.08.021 BindingDB Entry DOI: 10.7270/Q2TF011D |
More data for this Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Pin1 (Met1 to Glu163 residues) expressed in Escherichia coli using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as substrat... |
Bioorg Med Chem Lett 29: 1859-1863 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.045 BindingDB Entry DOI: 10.7270/Q2XG9VJR |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysis |
J Nat Prod 79: 697-703 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00396 BindingDB Entry DOI: 10.7270/Q2WQ078D |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysis |
J Nat Prod 79: 697-703 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00396 BindingDB Entry DOI: 10.7270/Q2WQ078D |
More data for this Ligand-Target Pair | |
DNA topoisomerase 1
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of DNA topoisomerase 1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.127976 BindingDB Entry DOI: 10.7270/Q2S75M49 |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.1c01222 BindingDB Entry DOI: 10.7270/Q2T72NFX |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] A
(Homo sapiens (Human)) | BDBM24777
(5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hyd...)Show InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University
| Assay Description The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan... |
Chem Biol Drug Des 87: 737-46 (2016)
Article DOI: 10.1111/cbdd.12708 BindingDB Entry DOI: 10.7270/Q2MG7N84 |
More data for this Ligand-Target Pair | |