BDBM24855 4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile::pyrrolopyrimidine, 13j

SMILES: N#Cc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc34)c12

InChI Key: InChIKey=PXAOTHLXABAQIT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24855   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM24855 (4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...) Show SMILES N#Cc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc34)c12 Show InChI InChI=1S/C19H18N6/c20-9-13-10-22-17-16(13)18(24-12-23-17)25-11-19(5-7-21-8-6-19)14-3-1-2-4-15(14)25/h1-4,10,12,21H,5-8,11H2,(H,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of AKT1 after 90 mins by IMAP assay				J Med Chem 53: 4615-22 (2010) Article DOI: 10.1021/jm1003842 BindingDB Entry DOI: 10.7270/Q24X580C
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM24855 (4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...) Show SMILES N#Cc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc34)c12 Show InChI InChI=1S/C19H18N6/c20-9-13-10-22-17-16(13)18(24-12-23-17)25-11-19(5-7-21-8-6-19)14-3-1-2-4-15(14)25/h1-4,10,12,21H,5-8,11H2,(H,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.5	22
Pfizer					Assay Description A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...				Bioorg Med Chem Lett 18: 3359-63 (2008) Article DOI: 10.1016/j.bmcl.2008.04.034 BindingDB Entry DOI: 10.7270/Q2M043QC
					More data for this Ligand-Target Pair