BDBM252635 US9458176, 32

SMILES: C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(Cl)c1)-c1cc(C)nc(C)c1

InChI Key: InChIKey=MRWHLXJCFGQNTP-CQSZACIVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252635   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM252635 (US9458176, 32) Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(Cl)c1)-c1cc(C)nc(C)c1 |r| Show InChI InChI=1S/C22H22ClF2N3O2/c1-12-8-16(9-13(2)26-12)20-18-6-7-29-14(3)11-28(18)21(27-20)15-4-5-19(17(23)10-15)30-22(24)25/h4-5,8-10,14,22H,6-7,11H2,1-3H3/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...				US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D
					More data for this Ligand-Target Pair