BDBM252798 US9458176, 195

SMILES: Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12

InChI Key: InChIKey=XEHQUSUNPCVWGP-GOSISDBHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252798   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM252798 (US9458176, 195) Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12 |r| Show InChI InChI=1S/C23H20F4N4O2/c1-13-7-16(8-14(2)29-13)21-19-5-6-32-18(10-24)12-31(19)22(30-21)15-3-4-20(17(9-15)11-28)33-23(25,26)27/h3-4,7-9,18H,5-6,10,12H2,1-2H3/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...				US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D
					More data for this Ligand-Target Pair