BDBM25477 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-phenyl-1,4-dihydropyrimidine-5-carboxamide::Dihydropyrimidine, 2

SMILES: CC1=C(C(NC(=N1)c1ccccc1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1

InChI Key: InChIKey=PXFUWAWMHRRZOE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM25477 (4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-...) Show SMILES CC1=C(C(NC(=N1)c1ccccc1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |c:5,t:1| Show InChI InChI=1S/C25H20FN5O/c1-15-22(25(32)29-20-11-12-21-18(13-20)14-27-31-21)23(16-7-9-19(26)10-8-16)30-24(28-15)17-5-3-2-4-6-17/h2-14,23H,1H3,(H,27,31)(H,28,30)(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...				J Med Chem 51: 6631-4 (2008) Article DOI: 10.1021/jm8005096 BindingDB Entry DOI: 10.7270/Q2F47MFZ
					More data for this Ligand-Target Pair