BDBM2586 3,4-Bis(3-indolyl)-3-pyrrolin-2-one::3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrol-2-one::Bisindolyl deriv. 8::Bisindolylmaleimide deriv. 8
SMILES: O=C1NCC(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
InChI Key: InChIKey=BLWFEWHEZAZRFX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM2586 (3,4-Bis(3-indolyl)-3-pyrrolin-2-one | 3,4-bis(1H-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Laboratoires Glaxo | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Kinase C (Rattus norvegicus (rat)) | BDBM2586 (3,4-Bis(3-indolyl)-3-pyrrolin-2-one | 3,4-bis(1H-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Roche Products Limited | Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his... | J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V | |||||||||||
More data for this Ligand-Target Pair |