BDBM26015 N-methyl-4-[(2-{[3-(trifluoromethyl)phenyl]amino}-1H-1,3-benzodiazol-5-yl)oxy]pyridine-2-carboxamide::arylaminobenzimidazole, 10

SMILES: CNC(=O)c1cc(Oc2ccc3nc(Nc4cccc(c4)C(F)(F)F)[nH]c3c2)ccn1

InChI Key: InChIKey=ANGSQGHXKXNCNG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM26015 (N-methyl-4-[(2-{[3-(trifluoromethyl)phenyl]amino}-...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4cccc(c4)C(F)(F)F)[nH]c3c2)ccn1 Show InChI InChI=1S/C21H16F3N5O2/c1-25-19(30)18-11-15(7-8-26-18)31-14-5-6-16-17(10-14)29-20(28-16)27-13-4-2-3-12(9-13)21(22,23)24/h2-11H,1H3,(H,25,30)(H2,27,28,29)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis					Assay Description To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...				J Med Chem 51: 7049-52 (2008) Article DOI: 10.1021/jm801050k BindingDB Entry DOI: 10.7270/Q2B56H1C
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM26015 (N-methyl-4-[(2-{[3-(trifluoromethyl)phenyl]amino}-...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4cccc(c4)C(F)(F)F)[nH]c3c2)ccn1 Show InChI InChI=1S/C21H16F3N5O2/c1-25-19(30)18-11-15(7-8-26-18)31-14-5-6-16-17(10-14)29-20(28-16)27-13-4-2-3-12(9-13)21(22,23)24/h2-11H,1H3,(H,25,30)(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	7.8	22
Novartis					Assay Description To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...				J Med Chem 51: 7049-52 (2008) Article DOI: 10.1021/jm801050k BindingDB Entry DOI: 10.7270/Q2B56H1C
					More data for this Ligand-Target Pair