Found 15 hits for monomerid = 26139 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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Similars
| MMDB PDB Article PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School
Curated by ChEMBL
| Assay Description Inhibitory activity against E. coli AmpC beta-lactamase. |
J Med Chem 41: 4577-86 (1998)
Article DOI: 10.1021/jm980343w BindingDB Entry DOI: 10.7270/Q22N51FX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-lactamase (TEM-1)
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli beta-lactamase |
J Med Chem 50: 5644-54 (2007)
Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 |
More data for this Ligand-Target Pair | |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Binding affinity of the compound towards AmpC beta-lactamase binding site from Escherichia coli |
J Med Chem 45: 3222-34 (2002)
BindingDB Entry DOI: 10.7270/Q2CN737M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acyl-protein thioesterase 2
(Homo sapiens (Human)) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB
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antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 529 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund
| Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... |
Chembiochem 14: 115-22 (2013)
Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 |
More data for this Ligand-Target Pair | |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School
Curated by ChEMBL
| Assay Description Compound was tested for its specificity against AmpC beta-lactamase |
J Med Chem 41: 4577-86 (1998)
Article DOI: 10.1021/jm980343w BindingDB Entry DOI: 10.7270/Q22N51FX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-chymotrypsin
(Bos taurus (bovine)) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School
Curated by ChEMBL
| Assay Description Compound was tested for its specificity against alpha-chymotrypsin |
J Med Chem 41: 4577-86 (1998)
Article DOI: 10.1021/jm980343w BindingDB Entry DOI: 10.7270/Q22N51FX |
More data for this Ligand-Target Pair | |
Trypsin
(Homo sapiens (Human)) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School
Curated by ChEMBL
| Assay Description Compound was tested for its specificity against beta-trypsin |
J Med Chem 41: 4577-86 (1998)
Article DOI: 10.1021/jm980343w BindingDB Entry DOI: 10.7270/Q22N51FX |
More data for this Ligand-Target Pair | |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inhibitory activity against beta-lactamase |
J Med Chem 45: 1712-22 (2002)
BindingDB Entry DOI: 10.7270/Q20C4WHD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of buffer |
J Med Chem 45: 1712-22 (2002)
BindingDB Entry DOI: 10.7270/Q20C4WHD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of buffer |
J Med Chem 45: 1712-22 (2002)
BindingDB Entry DOI: 10.7270/Q20C4WHD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of buffer |
J Med Chem 45: 1712-22 (2002)
BindingDB Entry DOI: 10.7270/Q20C4WHD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acyl-protein thioesterase 1
(Homo sapiens (Human)) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund
| Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... |
Chembiochem 14: 115-22 (2013)
Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 |
More data for this Ligand-Target Pair | |
Beta-lactamase AmpC
(Escherichia coli) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inhibitory activity against Amp C beta-Lactamase |
J Med Chem 46: 4265-72 (2003)
Article DOI: 10.1021/jm030266r BindingDB Entry DOI: 10.7270/Q29C6Z59 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fatty-acid amide hydrolase 1 (aa 30-579)
(Rattus norvegicus (rat)) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.4 | 37 |
University of Oxford
| Assay Description [3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase... |
J Med Chem 51: 7057-60 (2008)
Article DOI: 10.1021/jm801051t BindingDB Entry DOI: 10.7270/Q25D8Q58 |
More data for this Ligand-Target Pair | |
Monoglyceride lipase
(Homo sapiens (Human)) | BDBM26139
(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)Show InChI InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H | PDB MMDB
Reactome pathway KEGG
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Patents
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| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
| Assay Description The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ... |
J Med Chem 51: 7057-60 (2008)
Article DOI: 10.1021/jm801051t BindingDB Entry DOI: 10.7270/Q25D8Q58 |
More data for this Ligand-Target Pair | |