BDBM26670 2,3-diphenyl-1H-indole-7-carboxylic acid::cid_5003498::diphenylindole carboxylic acid, 3

SMILES: OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1

InChI Key: InChIKey=OLUDUXWVPIEHDA-UHFFFAOYSA-N

Data: 1 KI  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26670   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26670 (2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...) Show SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C21H15NO2/c23-21(24)17-13-7-12-16-18(14-8-3-1-4-9-14)19(22-20(16)17)15-10-5-2-6-11-15/h1-13,22H,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	550	-8.68	n/a	n/a	n/a	n/a	n/a	7.6	30
Vertex					Assay Description A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.				J Med Chem 51: 1972-5 (2008) Article DOI: 10.1021/jm701248t BindingDB Entry DOI: 10.7270/Q2HM56RQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26670 (2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...) Show SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C21H15NO2/c23-21(24)17-13-7-12-16-18(14-8-3-1-4-9-14)19(22-20(16)17)15-10-5-2-6-11-15/h1-13,22H,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Genzyme Corp. Curated by ChEMBL					Assay Description Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...				J Med Chem 55: 2641-8 (2012) Article DOI: 10.1021/jm2014698 BindingDB Entry DOI: 10.7270/Q2Q2418B
					More data for this Ligand-Target Pair				3D Structure (crystal)
streptokinase A precursor (Streptococcus pyogenes M1 GAS)	BDBM26670 (2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...) Show SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C21H15NO2/c23-21(24)17-13-7-12-16-18(14-8-3-1-4-9-14)19(22-20(16)17)15-10-5-2-6-11-15/h1-13,22H,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem	PCBioAssay	n/a	n/a	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2736PBV
					More data for this Ligand-Target Pair