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SMILES: Nc1n[nH]c2nc(nc(c12)C(F)(F)F)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1

InChI Key: InChIKey=DOBNNRUEFYWUQP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 269122   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))		BDBM269122
PNG
(N-[4-(3-Amino-4-trifluoromethyl-1H-pyrazolo[3,4-d]...)
Show SMILES Nc1n[nH]c2nc(nc(c12)C(F)(F)F)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C18H11ClF4N6O2S/c19-9-3-6-11(20)12(7-9)32(30,31)29-10-4-1-8(2-5-10)16-25-14(18(21,22)23)13-15(24)27-28-17(13)26-16/h1-7,29H,(H3,24,25,26,27,28)
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PC cid
PC sid
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US Patent
n/an/a 1.5n/an/an/an/a7.4n/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...

US Patent US9718825 (2017)


BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair