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SMILES: CCCOc1nc(cc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1

InChI Key: InChIKey=IMGHLDPCNZZUBQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 269148   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))		BDBM269148
PNG
(US9718825, Example 594)
Show SMILES CCCOc1nc(cc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1
Show InChI InChI=1S/C21H18ClF2N5O3S/c1-2-7-32-21-19-17(27-28-20(19)25)10-16(26-21)11-3-5-12(6-4-11)29-33(30,31)18-8-13(22)14(23)9-15(18)24/h3-6,8-10,29H,2,7H2,1H3,(H3,25,27,28)
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US Patent
n/an/a 1.5n/an/an/an/a7.4n/a



SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...

US Patent US9718825 (2017)


BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair