BDBM2694 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-2::Bisindolyl deriv. 22::CHEMBL218328
SMILES: CN1CCCC1CCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
InChI Key: InChIKey=LBFDERUQORUFIN-UHFFFAOYSA-N
Data: 6 IC50
PDB links: 1 PDB ID matches this monomer. 1 PDB ID contains this monomer as substructures.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM2694 (3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Glaxo | Assay Description The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi... | J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-Dependent Protein Kinase (PKA) (Rattus norvegicus (rat)) | BDBM2694 (3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Glaxo | Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone. | J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human)) | BDBM2694 (3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Scios, Inc. Curated by ChEMBL | Assay Description Inhibition of CaMK2delta | Bioorg Med Chem Lett 18: 2395-8 (2008) Article DOI: 10.1016/j.bmcl.2008.02.058 BindingDB Entry DOI: 10.7270/Q2QZ2BVW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-phosphoinositide-dependent protein kinase 1 (aa 51-359) (Homo sapiens (Human)) | BDBM2694 (3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...) | PDB GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
NAD-dependent deacetylase sirtuin 2 (Homo sapiens (Human)) | BDBM2694 (3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-Universität Freiburg Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT2 | J Med Chem 49: 7307-16 (2006) Article DOI: 10.1021/jm060118b BindingDB Entry DOI: 10.7270/Q2TQ616P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphorylase Kinase (Oryctolagus cuniculus (rabbit)) | BDBM2694 (3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Glaxo | Assay Description The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b. | J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4 | |||||||||||
More data for this Ligand-Target Pair |