BDBM270604 (S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((4-chlorophenyl)(1- (1-ethylpiperidin-4- yl)-1H-1,2,3-triazol- 4-yl)methyl) quinazoline- 4,6-diamine::US10059695, II-10::US10577352, Compound II-10
SMILES: CCN1CCC(CC1)n1cc(nn1)[C@@H](Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccc(Cl)cc1
InChI Key: InChIKey=YAKSRXYLNOGMCE-NDEPHWFRSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270604 ((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | 7.0 | 25 |
GILEAD SCIENCES, INC. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270604 ((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 527 | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270604 ((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM270604 ((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 527 | n/a | n/a | 7.0 | 25 |
GILEAD SCIENCES, INC. US Patent | Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-... | US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6 | |||||||||||
More data for this Ligand-Target Pair |