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SMILES: CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1

InChI Key: InChIKey=ITFLOJJAVYXCTM-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 27219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.5	30
Universite de Lyon					Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...				J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	7.5	30
Universite de Lyon					Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...				J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	30
Universite de Lyon					Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...				J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	7.5	30
Universite de Lyon					Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...				J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	7.5	30
Universite de Lyon					Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...				J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J
					More data for this Ligand-Target Pair