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BDBM276079 2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(5-fluoro-1H-triazol-4-yl)pyridine::US10071984, Example 41::US10174003, Example 41

SMILES: Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1F

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276079   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276079
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1F |(2.23,-3.53,;.74,-3.92,;-.16,-5.17,;-1.63,-4.69,;-1.63,-3.15,;-.16,-2.68,;.23,-1.19,;-.85,-.1,;-.46,1.39,;1.03,1.78,;1.43,3.27,;2.12,.7,;1.72,-.79,;2.81,-1.88,;4.3,-1.48,;5.39,-2.57,;5.79,-4.06,;6.88,-2.97,;-2.96,-2.38,;-2.96,-.84,;-4.3,-.07,;-5.63,-.84,;-5.63,-2.38,;-4.3,-3.15,;-4.3,1.47,;-3.05,2.37,;-3.53,3.84,;-5.07,3.84,;-5.54,2.37,;-6.88,1.6,)|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


BindingDB Entry DOI: 10.7270/Q24Q7X0X
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276079
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1F |(2.23,-3.53,;.74,-3.92,;-.16,-5.17,;-1.63,-4.69,;-1.63,-3.15,;-.16,-2.68,;.23,-1.19,;-.85,-.1,;-.46,1.39,;1.03,1.78,;1.43,3.27,;2.12,.7,;1.72,-.79,;2.81,-1.88,;4.3,-1.48,;5.39,-2.57,;5.79,-4.06,;6.88,-2.97,;-2.96,-2.38,;-2.96,-.84,;-4.3,-.07,;-5.63,-.84,;-5.63,-2.38,;-4.3,-3.15,;-4.3,1.47,;-3.05,2.37,;-3.53,3.84,;-5.07,3.84,;-5.54,2.37,;-6.88,1.6,)|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


BindingDB Entry DOI: 10.7270/Q2417053
More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276079
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1F |(2.23,-3.53,;.74,-3.92,;-.16,-5.17,;-1.63,-4.69,;-1.63,-3.15,;-.16,-2.68,;.23,-1.19,;-.85,-.1,;-.46,1.39,;1.03,1.78,;1.43,3.27,;2.12,.7,;1.72,-.79,;2.81,-1.88,;4.3,-1.48,;5.39,-2.57,;5.79,-4.06,;6.88,-2.97,;-2.96,-2.38,;-2.96,-.84,;-4.3,-.07,;-5.63,-.84,;-5.63,-2.38,;-4.3,-3.15,;-4.3,1.47,;-3.05,2.37,;-3.53,3.84,;-5.07,3.84,;-5.54,2.37,;-6.88,1.6,)|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


BindingDB Entry DOI: 10.7270/Q2417053
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276079
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1F |(2.23,-3.53,;.74,-3.92,;-.16,-5.17,;-1.63,-4.69,;-1.63,-3.15,;-.16,-2.68,;.23,-1.19,;-.85,-.1,;-.46,1.39,;1.03,1.78,;1.43,3.27,;2.12,.7,;1.72,-.79,;2.81,-1.88,;4.3,-1.48,;5.39,-2.57,;5.79,-4.06,;6.88,-2.97,;-2.96,-2.38,;-2.96,-.84,;-4.3,-.07,;-5.63,-.84,;-5.63,-2.38,;-4.3,-3.15,;-4.3,1.47,;-3.05,2.37,;-3.53,3.84,;-5.07,3.84,;-5.54,2.37,;-6.88,1.6,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


BindingDB Entry DOI: 10.7270/Q24Q7X0X
More data for this
Ligand-Target Pair