BDBM27668 2-[(4-fluoro-3-{[4-(2-phenoxypropanoyl)piperazin-1-yl]carbonyl}phenyl)methoxy]benzamide::substituted 2-benzyloxybenzamide, 10

SMILES: CC(Oc1ccccc1)C(=O)N1CCN(CC1)C(=O)c1cc(COc2ccccc2C(N)=O)ccc1F

InChI Key: InChIKey=FROGFYLCJZTDTH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27668   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27668 (2-[(4-fluoro-3-{[4-(2-phenoxypropanoyl)piperazin-1...) Show SMILES CC(Oc1ccccc1)C(=O)N1CCN(CC1)C(=O)c1cc(COc2ccccc2C(N)=O)ccc1F Show InChI InChI=1S/C28H28FN3O5/c1-19(37-21-7-3-2-4-8-21)27(34)31-13-15-32(16-14-31)28(35)23-17-20(11-12-24(23)29)18-36-25-10-6-5-9-22(25)26(30)33/h2-12,17,19H,13-16,18H2,1H3,(H2,30,33)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.4	22
KuDOS Pharmaceuticals Ltd					Assay Description A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...				Bioorg Med Chem Lett 18: 3942-5 (2008) Article DOI: 10.1016/j.bmcl.2008.06.025 BindingDB Entry DOI: 10.7270/Q2FF3QPX
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