BDBM27676 4,5-difluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]methoxy}benzamide::substituted 2-benzyloxyfluorobenzamide, 18

SMILES: NC(=O)c1cc(F)c(F)cc1OCc1ccc(F)c(c1)C(=O)N1CCNCC1

InChI Key: InChIKey=HUFRTUVZAZAWOZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27676   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27676 (4,5-difluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbony...) Show SMILES NC(=O)c1cc(F)c(F)cc1OCc1ccc(F)c(c1)C(=O)N1CCNCC1 Show InChI InChI=1S/C19H18F3N3O3/c20-14-2-1-11(7-12(14)19(27)25-5-3-24-4-6-25)10-28-17-9-16(22)15(21)8-13(17)18(23)26/h1-2,7-9,24H,3-6,10H2,(H2,23,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	7.4	22
KuDOS Pharmaceuticals Ltd					Assay Description A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...				Bioorg Med Chem Lett 18: 3942-5 (2008) Article DOI: 10.1016/j.bmcl.2008.06.025 BindingDB Entry DOI: 10.7270/Q2FF3QPX
					More data for this Ligand-Target Pair