BDBM27679 3,6-difluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]methoxy}benzamide::substituted 2-benzyloxyfluorobenzamide, 21
SMILES: NC(=O)c1c(F)ccc(F)c1OCc1ccc(F)c(c1)C(=O)N1CCNCC1
InChI Key: InChIKey=ADLUIRCSIARXRQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM27679 (3,6-difluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbony...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
KuDOS Pharmaceuticals Ltd | Assay Description A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin... | Bioorg Med Chem Lett 18: 3942-5 (2008) Article DOI: 10.1016/j.bmcl.2008.06.025 BindingDB Entry DOI: 10.7270/Q2FF3QPX | |||||||||||
More data for this Ligand-Target Pair |