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BDBM27820 2-[(2-{[2-fluoro-4-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide::4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 3

SMILES: CCCN1CCC=C(C1)c1ccc(Nc2nc(Nc3ccccc3C(N)=O)c3cc[nH]c3n2)c(F)c1

InChI Key: InChIKey=CGLNKCUZVMEOBR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27820   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27820
PNG
(2-[(2-{[2-fluoro-4-(1-propyl-1,2,5,6-tetrahydropyr...)
Show SMILES CCCN1CCC=C(C1)c1ccc(Nc2nc(Nc3ccccc3C(N)=O)c3cc[nH]c3n2)c(F)c1 |c:6|
Show InChI InChI=1S/C27H28FN7O/c1-2-13-35-14-5-6-18(16-35)17-9-10-23(21(28)15-17)32-27-33-25-20(11-12-30-25)26(34-27)31-22-8-4-3-7-19(22)24(29)36/h3-4,6-12,15H,2,5,13-14,16H2,1H3,(H2,29,36)(H3,30,31,32,33,34)
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MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/a7.522



GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 469-73 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.046
BindingDB Entry DOI: 10.7270/Q2J67F88
More data for this
Ligand-Target Pair