BDBM27832 2-{[2-({2,5-dimethoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluorobenzamide::4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 16

SMILES: COc1cc(N2CCN(CC2)C(C)C)c(OC)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1

InChI Key: InChIKey=KXYLUJKFWHBNMG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM27832 (2-{[2-({2,5-dimethoxy-4-[4-(propan-2-yl)piperazin-...) Show SMILES COc1cc(N2CCN(CC2)C(C)C)c(OC)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C28H33FN8O3/c1-16(2)36-10-12-37(13-11-36)21-15-22(39-3)20(14-23(21)40-4)33-28-34-26-17(8-9-31-26)27(35-28)32-19-7-5-6-18(29)24(19)25(30)38/h5-9,14-16H,10-13H2,1-4H3,(H2,30,38)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 469-73 (2009) Article DOI: 10.1016/j.bmcl.2008.11.046 BindingDB Entry DOI: 10.7270/Q2J67F88
					More data for this Ligand-Target Pair